Endocrine Abstracts

Infertility affects 1 in 20 Australia men of reproductive age, and for the majority, the causes remain unknown. In an effort to identify addition key pathways and proteins involved in male fertility we undertook a random mouse mutagenesis screen. In the process we identified the Mot1 line which carries a point mutation in the Rabl2 gene. Mot1 homozygous male are sterile, have a reduced daily sperm output, short sperm tails and drastically reduced progressive sperm motil...